Alunib 90 | Non-Small Cell Lung Cancer | 7pcs Tablet Price | Get Discount
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Alunib 90mg Tablet

Generic: Brigatinib

Type: Tablet

Pack Size: 7pcs

Alunib 90mg Tablet is a targeted therapy addressing the unique needs of NSCLC patients with specific genetic mutations driving cancer growth.


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Discount Price: ৳ 7980
MRP: ৳ 8400 5% Off

⪼ Save  ৳: 420  in this Product


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✅ Description:

  • Alunib 90mg Tablet (Brigatinib) offers hope and transformation for those facing non-small cell lung cancer (NSCLC).
  • Jenphar Bangladesh Ltd. is a trusted source for this targeted oral medication designed to address specific genetic mutations in metastatic NSCLC.
  • Clinical trials have shown significant enhancement in progression-free survival compared to traditional chemotherapy.
  • Offers new hope for patients who may not have responded well to previous treatments.
  • Alunib 90mg Tablet is a targeted therapy addressing the unique needs of NSCLC patients with specific genetic mutations driving cancer growth.'s oral form provides convenience, eliminating the need for frequent hospital visits.
  • Administered at home for a more manageable and less disruptive treatment process.
  • Generally well-tolerated, Alunib 90mg Tablet's benefits are carefully weighed against potential risks by oncologists.
  • Consultation with a healthcare provider is crucial for a personalized approach to treatment.
  • Alunib 90mg Tablet should only be taken under the guidance of a qualified oncologist with expertise in lung cancer treatment.
  • Individual medical condition assessment, tests, and treatment alignment are determined through consultation.
  • Trepmac 90 mg has the potential to reshape NSCLC treatment, offering hope and progress.
  • Information is foundational; consult with a healthcare professional for a personalized treatment plan.

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✔️ Uses of Alunib 90

Treat a certain type of non-small cell lung cancer (NSCLC)

✔️ Side Effects of Alunib 90
  • Interstitial Lung Disease (ILD)/Pneumonitis
  • Hypertension
  • Bradycardia
  • Visual Disturbance
  • Creatine Phosphokinase (CPK) Elevation
  • Pancreatic Enzyme Elevation
  • Hyperglycemia
✔️ How does Alunib 90 work?

Tyrosine Kinase Inhibitor (TKI):

  • Demonstrates in vitro activity against multiple kinases, including:
    • ALK (Anaplastic Lymphoma Kinase)
    • ROS1
    • IGF-1R (Insulin-like Growth Factor-1 Receptor)
    • FLT-3
    • EGFR (Epidermal Growth Factor Receptor) deletion and point mutations.

Inhibition of ALK Signaling:

  • Brigatinib inhibits autophosphorylation of ALK (Anaplastic Lymphoma Kinase).
  • Inhibits ALK-mediated phosphorylation of downstream signaling proteins:
    • STAT3
    • AKT
    • ERK1/2
    • S6

Antitumor Activity:

  • Exhibits in vivo antitumor activity against mutant forms of EML4-ALK, including G1202R and L1196M mutants.
  • Effective against non-small cell lung cancer (NSCLC) tumors in patients who have progressed on crizotinib.

Activity Against ALK-Driven Tumors:

  • Reduces tumor burden.
  • Prolong survival in mice implanted intracranially with an ALK-driven tumor cell line.

Brigatinib's ability to inhibit key signaling pathways and its antitumor activity against various mutations, especially in the context of ALK-driven tumors, highlights its potential as a targeted therapy for certain types of cancer, particularly non-small cell lung cancer. These findings suggest a promising role for Brigatinib in the treatment of patients who have developed resistance to previous therapies, such as crizotinib.

✔️ Quick Suggestions:
  • Limit sun exposure during Brigatinib treatment and for at least 5 days after the last dose. Brigatinib may increase sensitivity to sunlight, leading to a higher risk of sunburn.
  • Protective Measures:
    • Wear a hat and protective clothing when in the sun.
    • Use a broad-spectrum sunscreen with SPF 30 or greater.
    • Apply lip balm with SPF protection.
  • Refrain from consuming grapefruit or grapefruit juice while undergoing Brigatinib treatment. Grapefruit may impact Brigatinib levels in the blood, potentially affecting its efficacy or safety.
✔️ Indication of Alunib 90

Alunib 90 is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic Non-Small Cell Lung Cancer (NSCLC) who have progressed on or are intolerant to Crizotinib.

✔️ Pharmacology
  • Mechanism of Action: Brigatinib is a tyrosine kinase inhibitor with in vitro activity against multiple kinases, including ALK, ROS1, IGF-1R, FLT-3, EGFR, and more.
  • Absorption: The median time to peak concentration (Tmax) ranges from 1 to 4 hours after single oral doses of Brigatinib.
  • Distribution: Brigatinib is 66% bound to human plasma proteins, and the mean apparent volume of distribution (Vz/F) at steady-state is 153 L.
  • Elimination: The mean apparent oral clearance (CL/F) at steady-state is 12.7 L/h, and the plasma elimination half-life is 25 hours.
  • Metabolism: Primarily metabolized by CYP2C8 and CYP3A4, with N-demethylation and cysteine conjugation as major pathways.
  • Excretion: About 65% of the administered dose is recovered in feces and 25% in urine, with unchanged Brigatinib being the major circulating component.
✔️ Dosage & Administration of Alunib 90
  • Start with 90 mg orally once daily for the first 7 days.
  • If tolerated, increase to 180 mg orally once daily.
  • Safety and efficacy in pediatric patients not established.
  • Administer until disease progression or unacceptable toxicity.
  • If interrupted for 14 days or longer, resume at 90 mg once daily for 7 days before increasing.
  • Tablets may be taken with or without food, swallowed whole, not crushed or chewed.
✔️ Interaction
  • Increased Plasma Concentrations: Avoid strong CYP3A inhibitors.
  • Decreased Plasma Concentrations: Avoid strong CYP3A inducers.
  • Altered Plasma Concentrations: Induces CYP3A, and may decrease concentrations of CYP3A substrates.
✔️ Contraindications

Hypersensitivity to Brigatinib or any components.

✔️ Pregnancy & Lactation
  • Pregnancy: Potential risk to the fetus.
  • Lactation: Advised not to breastfeed during treatment.
✔️ Precautions & Warnings
  • Interstitial Lung Disease (ILD)/Pneumonitis: Promptly evaluate new or worsening respiratory symptoms.
  • Hypertension: Monitor blood pressure; withhold or discontinue for Grade 3 or 4 hypertension.
  • Bradycardia: Monitor heart rate; caution with bradycardia-inducing agents.
  • Visual Disturbance: Withhold, obtain an ophthalmologic evaluation for Grade 2 or greater severity.
  • CPK Elevation: Monitor for muscle pain, tenderness, or weakness; withhold for Grade 3 or 4 CPK elevation.
  • Pancreatic Enzyme Elevation: Monitor amylase and lipase; withhold for Grade 3 or 4 elevation.
  • Hyperglycemia: Monitor serum glucose; adjust antihyperglycemic medications as needed.
✔️ Storage Conditions

Keep below 30°C, away from light & moisture. Keep out of the reach of children.

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Check our pricing section for Alunib 90mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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